NEW PRODUCTS

[#BE0331]InVivoMAb anti-human CD3

학술부 2020-03-11 Views 1,702


About InVivoMAb anti-human CD3




The OKT-3 monoclonal antibody reacts with human CD3ε, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection.



​ 

InVivoMAb anti-human CD3 Specifications

​

Isotype

Mouse IgG2a, κ


Recommended Isotype Control(s)

InVivoMAb mouse IgG2a isotype control, unknown specificity(BE0085) 

 

Recommended InVivoPure Dilution Buffer

InVivoPure pH 7.0 Dilution Buffer(IP0070) 

 

Immunogen

Not available or unknown

​

Reported Applications
  • in vitro T cell stimulation/activation
  • in vivo T cell depletion in humanized mice
  • ex vivo T cell inhibition for xenografts
  • Flow cytometry


Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay


Purity
  • >95%
  • Determined by SDS-PAGE


Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives


Sterility

0.2 μM filtered


Production

Purified from tissue culture supernatant in an animal free facility

​

Purification

Protein G


Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.


RRID

AB_1107632

​

Molecular Weight

150 kDa


List
Prev
[#BE0323]InVivoMAb anti-mouse TL1A (TNFSF15)
Next
[#BE0325]InVivoMAb anti-West Nile/dengue virus E protein