Immune checkpoints are regulators of the immune system which prevent the immune system from attacking self-antigens indiscriminately. While this is critical to preventing auto-immune disease it also causes the immune system to be ineffective in eradicating or suppressing cancer.
Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can be readily blocked by antibodies.
Blocking these immune checkpoints allows antitumor activity to resume and is among the most promising approaches to activating therapeutic anti-tumor immunity.
Bio X Cell offers an extensive selection of antibodies targeting mouse immune checkpoint proteins.
Clone LOB12.3 - This clone was first published in 2002 by Vadim Y. Taraban et al. The immunogen used to create this antibody is reported as a mouse CD137 human Fc fusion protein.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/12516549
Clone 3H3 - This clone was first published in 1997 by Walter W. Shuford et al. The immunogen used to create this antibody is reported as a mouse CD137 human Fc fusion protein.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/9206996
Clone 17B5 - Origin information unknown
Clone LOB12.3 - This clone was first published in 2002 by Toshiro Futagawa et al. The immunogen used to create this antibody is reported as mouse 4-1BBL transfected NRK cells. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/11867564
Clone FGK4.5 - This clone was created in 1996 by Drs. J. Andersson and A. Rolink. The immunogen used to create this antibody is reported as recombinant mouse CD40 fusion protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/8885865
Clone MR-1 - This clone was first published in 1992 by Dr. Randolph. J. Noelle et al. The immunogen used to create this antibody is reported as activated mouse TH1 clone D1.6. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/1378631
Clone MIAP301 - Origin information unknown
Clone MIAP410 - This clone was first published in 2000 by Xin Han et al. The immunogen used to create this antibody is reported as purified human placental CD47. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/10964914
Clone 1G10 - This clone was first published in 1992 by Ziba Razi-Wolf et al. The immunogen used to create this antibody is reported as dibutyryl cAMP-Activated 5C2 cells. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/1373896
Clone 16-10A1 - This clone was first published in 1994 by Gordon D.Powers et al. The immunogen used to create this antibody is reported as CHO cells transfected with mouse CD80. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/7509723
Clone GL-1 - This clone was first published in 1993 by Karen S. Hathcock et al. The immunogen used to create this antibody is reported as LPS-activated CBA/Ca mouse splenic B cells. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/7694361
Clone MJ18 - This clone was first published in 2008 by Osamu Nagashima et al. The immunogen used to create this antibody is reported as a mouse B7-H3 IgG2a fusion protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/18768862
Clone 9H10 - This clone was first published in 1995 by Matthew F. Krummel and James P. Allison. The immunogen used to create this antibody is reported as mouse CTLA-4-human IgG1 fusion protein.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/7543139
Clone 9D9 - Origin information unknown
Clone UC10-4F10-11 - This clone was first published in 1994 by Theresa L. Walunas. The immunogen used to create this antibody is reported as mouse CTLA-4 IgG2a fusion protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/7882171
Clone C9B7W - This clone was first published in 1996 by Aymen Al-Shamkhani et al. The immunogen used to create this antibody is reported as recombinant mouse OX40-CD4 chimeric protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/12209638
Clone OX-86 - This clone was first published in 1996 by Aymen Al-Shamkhani et al. The immunogen used to create this antibody is reported as recombinant mouse OX40-CD4 chimeric protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/8765008
Clone RM134L - This clone was first published in 1999 by Yoshinori Seko et al. The immunogen used to create this antibody is reported as rat NRK-52E cells transfected with mouse OX40L. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/10440754
Clone RMP1-14 - This clone was first published in 2003 by Takanori Kanai et al. The immunogen used to create this antibody is reported as Syrian hamster BKH cells transfected with mouse PD-1 cDNA.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/14530338
Clone 29F.1A12 - This clone was first published in 2003 by Spencer C. Liang et al. The immunogen used to create this antibody is reported as a recombinant mouse PD-1-Ig fusion protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/14515254
Clone J43 - This clone was first published in 1996 by Yasutoshi Agata et al. The immunogen used to create this antibody is reported as Syrian hamster BKH cells transfected with mouse PD-1 cDNA. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/8671665
Clone RMP1-14 - This clone was first published in 2002 by Michael J. Eppihimer et al. The immunogen used to create this antibody is reported as CHO-mPD-L1 transfectants. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/11932780
Clone TY25 - This clone was first published in 2002 by Tomohide Yamazaki et al. The immunogen used to create this antibody is reported as mouse B7-DC-transfected RAW264.7 cells. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/12421930
Clone RMT1-10 - This clone was first published in 2006 by Atsuki Fukushima et al. The immunogen used to create this antibody is reported as a full-length mouse TIM-1-Ig fusion protein. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/17174273
Clone 3B3 - This clone was first published in 2005 by Sarah E Umetsu et al. The immunogen used to create this antibody is reported as a mouse TIM-1 (signal and IgV domains)/mouse IgG2a Fc fusion protein.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/15793575
Clone 3D10 - This clone was first published in 2005 by Sarah E Umetsu et al. The immunogen used to create this antibody is reported as a mouse TIM-1 (signal and IgV domains)/mouse IgG2a Fc fusion protein.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/15793575
Clone RMT3-23 - This clone was first published in 2006 by Tsunekazu Oikawa et al. The immunogen used to create this antibody is reported as recombinant mouse TIM-3. The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/16982862
Clone B8.2C12 - Origin information unknown
Clone 13F3 - This clone was first published in 2011 by Li Wang et al. The immunogen used to create this antibody is reported as EL4 cells overexpressing mouse VISTA-RFP followed by a boost with VISTA-Ig fusion protein.
The original publication describing the generation of this antibody can be found here: https://www.ncbi.nlm.nih.gov/pubmed/21383057