RecombiMAb anti-mouse VEGFR-2

Clone DC101-CP132
Catalog # CP132
Category in vivo Recombinant Antibodies
Price
Size Regular Price
1mg $ 217.00
5mg $ 843.00
25mg $ 2,942.00
50mg $ 4,229.00
100mg $ 5,910.00
About RecombiMAb anti-mouse VEGFR-2

The DC101-CP132 monoclonal antibody is a chimeric version of the original DC101 antibody. The variable domain sequences are identical to the original DC101 but the constant region sequences have been switched from rat IgG1 to mouse IgG2a. The DC101-CP132 antibody contains no Fc mutations just as the original rat IgG1 antibody does not. The DC101-CP132 monoclonal antibody reacts with mouse VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1. VEGFR-2 is a member of the tyrosine protein kinase family. Upon binding to its ligand VEGF, VEGFR-2 pays key roles in vascular development and permeability. VEGFR-2 is expressed on endothelial cells at high levels in adult heart, lung, kidney, brain, and skeletal muscle as well as other tissues at lower levels. The DC101 antibody has been shown to inhibit VEGFR-2 signaling in vivo.

See the references for the original rat IgG1 DC101 antibody (https://bioxcell.com/catalogsearch/result/?q=BP0060). 

RecombiMAb anti-mouse VEGFR-2 Specifications
IsotypeMouse IgG2a, κ
Recommended Isotype Control(s)InVivoPlus mouse IgG2a isotype control, unknown specificity
Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
ImmunogenMouse VEGFR-2-SEAPs soluble receptor
Reported Applicationsin vivo blocking of VEGF/VEGFR-2 signaling*
in vitro blocking of VEGFR signaling*
Western blot*
*Reported for the original rat IgG1 DC101 antibody
FormulationPBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin<1EU/mg (<0.001EU/μg)
Determined by LAL gel clotting assay
Aggregation<5%
Determined by DLS
Purity>95%
Determined by SDS-PAGE
Sterility0.2 µm filtration
ProductionPurified from CHO cell supernatant in an animal free facility
PurificationProtein G
Molecular Weight150 kDa
Murine Pathogen TestsEctromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
Application References