InVivoSIM anti-human IL-17A (Secukinumab Biosimilar)

Clone Secukinumab
Catalog # SIM0013
Category InVivoSIM™ Biosimilar Antibodies
Price
Size Regular Price
1mg $ 205.00
5mg $ 795.00
25mg $ 2,775.00
50mg $ 3,990.00
100mg $ 5,575.00
About InVivoSIM anti-human IL-17A (Secukinumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Secukinumab making it ideal for research use. This Secukinumab biosimilar reacts with human IL-17A, a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. Secukinumab neutralizes IL-17A. 

InVivoSIM anti-human IL-17A (Secukinumab Biosimilar) Specifications
Isotypehuman IgG1
Recommended Isotype Control(s)InVivoPlus™ human IgG1 isotype control
Recommended Dilution BufferInVivoPure™ pH 7.0 Dilution Buffer
ImmunogenHuman IL-17A
Reported Applications
  • Functional assays
  • ELISA
  • Immunofluoresence
  • Immunohistochemistry
  • Flow Cytometry
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <1EU/mg (<0.001EU/μg)
  • Determined by LAL gel clotting assay
Aggregation
  • <5%
  • Determined by DLS
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility0.2 μM filtered
ProductionPurified from cell culture supernatant
PurificationProtein A
Molecular Weight150 kDa
Murine Pathogen Test Results
  • Mouse Norovirus: Negative
  • Mouse Parvovirus: Negative
  • Mouse Minute Virus: Negative
  • Mouse Hepatitis Virus: Negative
  • Reovirus Screen: Negative
  • Lymphocytic Choriomeningitis virus: Negative
  • Lactate Dehydrogenase-Elevating Virus: Negative
  • Mouse Rotavirus: Negative
  • Theiler’s Murine Encephalomyelitis: Negative
  • Ectromelia/Mousepox Virus: Negative
  • Hantavirus: Negative
  • Polyoma Virus: Negative
  • Mouse Adenovirus: Negative
  • Sendai Virus: Negative
  • Mycoplasma Pulmonis: Negative
  • Pneumonia Virus of Mice: Negative
  • Mouse Cytomegalovirus: Negative
  • K Virus: Negative
StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
Application References