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[#BE0324]InVivoMAb anti-human/mouse denatured collagen type-I (RGD motif

관리자 2020-03-12 Views 2,578

About InVivoMAb anti-human/mouse denatured collagen type-I (RGD motif)

The XL313 monoclonal antibody reacts with denatured human and mouse collagen type-I but not native collagen type-I. The antibody reacts with the RGD motif. Collagen is a fibrous multi-chain triple helical protein that exists in numerous forms. Collagen type-I is the most abundant collagen type in the extracellular matrix. Collagen type-I, type-III, collagen type-IV and collagen type-V have been shown to be associated with all pre-existing blood vessels in vivo. Denaturation of the native three-dimensional structure of collagen is thought to expose cryptic regulatory regions that control angiogenesis. The XL313 antibody has been shown to inhibit angiogenesis in chick embryos and enhance the anti-tumor activity of anti-PD-L1 therapy in vivo. XL313 administration has also been shown to inhibit Lewis lung carcinoma tumor growth in C57BL/6 mice (shown in US Patent No: 7588760B2).

InVivoMAb anti-human/mouse denatured collagen type-I (RGD motif) Specifications

Isotype

Mouse IgG1, κ

Recommended Isotype Control(s)InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Synthetic RGD containing human collagen peptides

Reported Applications
  • Western blot
  • Immunofluorescence
  • in vivo administration (see description)
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Molecular Weight

150 kDa

RRID

AB_2819051

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

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