InVivoSIM anti-human PD-L1 (Atezolizumab Biosimilar)

Clone Atezolizumab
Catalog # SIM0009
Category InVivoSIM™ Biosimilar Antibodies
Price
Size Regular Price
1mg $ 205.00
5mg $ 795.00
25mg $ 2,775.00
50mg $ 3,990.00
100mg $ 5,575.00
About InVivoSIM anti-human PD-L1 (Atezolizumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Atezolizumab making it ideal for research use. This Atezolizumab biosimilar reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. Atezolizumab blocks the interaction of PD-L1 with PD-1 and CD80. 

InVivoSIM anti-human PD-L1 (Atezolizumab Biosimilar) Specifications
Isotypehuman IgG1
Recommended Isotype Control(s)InVivoPlus™ human IgG1 isotype control
Recommended Dilution BufferInVivoPure™ pH 7.0 Dilution Buffer
ImmunogenNot available or unknown
Reported Applications
  • Flow Cytometry
  • Western Blot
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <1EU/mg (<0.001EU/μg)
  • Determined by LAL gel clotting assay
Aggregation
  • <5%
  • Determined by DLS
Sterility0.2 μM filtered
ProductionPurified from cell culture supernatant
PurificationProtein A
Molecular Weight150 kDa
Murine Pathogen Test Results
  • Mouse Norovirus: Negative
  • Mouse Parvovirus: Negative
  • Mouse Minute Virus: Negative
  • Mouse Hepatitis Virus: Negative
  • Reovirus Screen: Negative
  • Lymphocytic Choriomeningitis virus: Negative
  • Lactate Dehydrogenase-Elevating Virus: Negative
  • Mouse Rotavirus: Negative
  • Theiler’s Murine Encephalomyelitis: Negative
  • Ectromelia/Mousepox Virus: Negative
  • Hantavirus: Negative
  • Polyoma Virus: Negative
  • Mouse Adenovirus: Negative
  • Sendai Virus: Negative
  • Mycoplasma Pulmonis: Negative
  • Pneumonia Virus of Mice: Negative
  • Mouse Cytomegalovirus: Negative
  • K Virus: Negative
StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
Application References